Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria

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Silver enhances antibiotic activity against gram-negative bacteria.

A declining pipeline of clinically useful antibiotics has made it imperative to develop more effective antimicrobial therapies, particularly against difficult-to-treat Gram-negative pathogens. Silver has been used as an antimicrobial since antiquity, yet its mechanism of action remains unclear. We show that silver disrupts multiple bacterial cellular processes, including disulfide bond formatio...

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ژورنال

عنوان ژورنال: Science Translational Medicine

سال: 2013

ISSN: 1946-6234,1946-6242

DOI: 10.1126/scitranslmed.3006276